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Combined with these findings, it is possible that PTEN is a downstream molecule involved in nicotine regulation of pain and regeneration, but the specific mechanism of how nicotine regulates PTEN needs to be further studied in the future

Theres yet another serious issue that B12 deficiency causes and thats accumulation of homocysteine and methylmalonic acid in the blood but it doesnt produce any specific symptoms a blood test would be able to reveal these issues (EFSA, 2015