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While these short-term dose-response assays assess the cytotoxic effect of APR-246, we were also interested in the potential cytostatic effects of APR-246

Clin Pharmacol Ther 34(6):718723 Walle T, Byington RP, Furberg CD, McIntyre KM, Vokonas PS (1985) Biologic determinants of propranolol disposition: results from 1308 patients in the Beta-Blocker Heart Attack Trial

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Pharmacokinetics (PK) and pharmacodynamics (PD) of RG7112, an oral murine double minute 2 (MDM2) antagonist, in patients with leukemia and solid tumor