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Further work will be aimed at knocking down the expression of BMAL1 to see the effect this has on the other clock component genes as well as NRF2 and GSH levels

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3.2.1 Metformin 3.2.1.1 Basic science research Despite metformin being the most widely prescribed drug for the treatment of T2DM and being considered an essential medicine by the World Health Organization, its exact mechanism of action is still debated

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Tumor temperature increased to 52 and 57 C and tumor tissue was strongly eradicated, the expression of Bcl-2 and Ki67 in tumor tissue was significantly decreased