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This risk was 1.5 times higher in patients receiving a daily metformin dose between 1 g and 2 g and 4.3 times higher in patients receiving daily metformin doses exceeding 2 g

The monoamine theory of depression led to the development of both tricyclic antidepressants (TCAs) and serotonin-specific reuptake inhibitors (SSRIs), which both increase central monoamine levels