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Aini, H

Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’InsideTM) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders

DOI: 10.1677/JME-09-0090 Jiang, Y.J., Barish, G., Lu, B., Evans, R.M., Crumrine, D., Schmuth, M., Elias, P.M., Feingold, K.R

J Thorac Cardiovasc Surg 165(1):398-400, 2023

1 2 Journal of Applied Physiology

Oral administration of the probiotic Pediococcus pentosaceus SMM914 (SMM914) can enhance the abundance of gut probiotics and strengthen the tryptophan-melatonin pathway, increasing endogenous anti-inflammatory factors such as 6-hydroxymelatonin and secondary taurine in the lung environment, reducing the polarization of macrophages to the M1 phenotype, and finally alleviating oxidative stress in COPD mice (69)