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Therapeutic doses of regular (non-enteric coated) aspirin are absorbed rapidly within two hours

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A major contributor is iron-dependent Fenton chemistry, in which ferrous iron (Fe 2 ) reacts with hydrogen peroxide to generate hydroxyl radicals capable of oxidizing PUFA-PLs into lipid peroxides (PUFA-OOH) [14]

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As a result, electrons accumulate at coenzyme Q, promoting incomplete oxygen reduction and excessive superoxide generation, thereby intensifying mitochondrial oxidative stress [28, 79]