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R., Basha, S

Its inclusion in the Category 2 restricted list has drawn criticism from clinicians who point to its legitimate international approval record as evidence that the safety concerns cited by the FDA are inconsistent with the global clinical literature

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Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs

As mentioned above, mutation of the latter residues leads to a pronounced lowering of the MGST1 activity and mutation of the former leads to an activity decrease as well as a 67 fold increase in K m for GSH (Table 1)

For instance, miR-145, which is able to target fascin is significantly reduced in CRC, where metastases inversely correlates with miR-145 [109]