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The generation of large amounts of biomedical data, or big data, ranging from clinical information in electronic health records (EHRs) to the molecular measurement of analytes using different omics platforms (e.g., genomics, transcriptomics, proteomics, and metabolomics) has also prompted the need for analytical frameworks that can holistically interrogate disease pathobiology

Thus, damage to mitochondrial DNA and loss of can further increase ROS production, thereby creating a cycle of dysfunction that includes increased ROS production by the respiratory chain, activation of signal transduction pathways, and potentially, leading to apoptosis or necrosis, as well as the release of cytochrome c, which triggers apoptosis

Shock 51 , 580584 (2019)

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The reversible loss, typically referred to as a temporary threshold shift (TTS), results from exposures to moderately intense sounds, such as might be encountered at a philharmonic orchestra concert