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Cytosolic Ca 2+ is taken up by a voltage-dependent anion-selective channel and mitochondrial calcium uniporter channels, leading to accumulation of Ca 2+ in the mitochondrial matrix

Although the proposed vicious cycle remains a working hypothesis requiring further validation, understanding this interplay may help identify novel biomarkers, stratify patients by metabolic phenotype, and guide precision therapies for HF

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HA conceptualized the study, designed research, performed experiments, analyzed data, and co-wrote the manuscript with input from all co-authors

Global Propionic Acidemia Market Forecast and Regional Outlook: Market Size & Growth Projections: 2025 Market Size: USD 1.34 billion 2026 Market Size: USD 1.39 billion Projected Market Size: USD 2.02 billion by 2035 Growth Forecasts: 4.2% CAGR (2026-2035) Key Regional Dynamics: Largest Region: North America (35% Share by 2035) Fastest Growing Region: Asia Pacific Dominating Countries: United States, Germany, United Kingdom, Japan, China Emerging Countries: China, India, Japan, South Korea, Malaysia Last updated on : 16 September, 2025 Propionic Acidemia Market Growth Drivers and Challenges: Growth Drivers Growing Awareness About Propionic Acidemia Growing public awareness campaigns and initiatives are raising awareness of PA globally, leading to earlier diagnosis and treatment