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Notably, in the setting of high-frequency and prolonged sympathetic activation such as during acute myocardial ischemia, additional sympathetic co-transmitters other than norepinephrine (NE) are co-released from sympathetic post-ganglionic efferent fibers, including ATP, galanin and neuropeptide Y (NPY) (Herring 2015)

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[DOI] [PubMed] [Google Scholar] 43.Board PG, Menon D

Clonal selection may facilitate the initial survival of malignant cells during anticancer therapy, permitting a minority of cancer cells to acquire additional drug-resistant mutations, thereby facilitating disease progression