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Similar content being viewed by others Introduction Mitochondrial dysfunction plays a central role in a wide range of age-associated disorders and various forms of cancer [1]

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Lastly, MNPs containing siRNA against ferroptosis suppressor glutathione peroxidase 4 (GPX4) induced marked cell viability loss in vitro , and in vivo showed tumor enrichment, target engagement and reduced tumor burden

4 A ) was driven by the dorsal part of the hippocampal formation, which showed significantly higher values of Olig2-IR in the IGF-1 group in both dorsal CA and hilus fields ( p = 0.03 and p = 0.005, respectively

Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, Rabinowitz JD, Cantley LC, Thompson CB, Vander Heiden MG, Su SM: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate