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4G, with significant pathways including Arachidonic acid metabolism (P = 0.0009), Biosynthesis of unsaturated fatty acids (P = 0.0010), Linoleic acid metabolism (P = 0.0335), and Ferroptosis (P = 0.0398)

The ILD component of CTD is a major determinant of morbidity and mortality in CTDs and new developments from clinical trials have started yielding results to fill the urgent need for new therapies for CTD-ILD

Nat Rev Drug Discov 7: 504516 [DOI] [PubMed] [Google Scholar] Comoglio P.M., Trusolino L

Hematol Transfus Cell Ther

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Geographic location affects selenium status : UK soils are selenium-deficient, meaning men consuming primarily local produce may require dietary adjustments or supplementation to maintain optimal levels