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SREBP1 site 1 protease inhibitor PF-429242 suppresses renal cell carcinoma cell growth

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Researchers have investigated this compound as a tool for modulating NNMT activity in in vitro and preclinical models, providing insight into the enzyme's role in metabolic homeostasis

By modulating NNMT activity in experimental systems, researchers evaluate downstream shifts in methyl donor utilization, enzymatic output, and pathway-level signaling

doi: 10.1182/blood.2021012811 90 SaltarellaIMorabitoFGiulianiNTerragnaCOmedPPalumboAet al

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