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In addition, SIRT1 reduces oxidative stress and inflammation by inhibiting the nuclear factor kappa B (NF-B) signaling pathway, resulting in decreased production of inflammatory cytokines, including IL-1, interleukin-6 (IL-6), tumor necrosis factor (TNF-), and ROS (133135)

Shih, J

The HPA axis, glucocorticoids, and the stress response The HPA axis is a major stress response system in the body, with neurons in the hypothalamic paraventricular nucleus (PVN) synthesizing and secreting corticotropin-releasing hormone (CRH) and antidiuretic hormone (ADH) in response to stress (133)