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In contrast, due to the competition of tumor cells for glutamine in the TME, glutamine deficiency in immune cells leads to the inhibition of mTOR activation in immune cells [23], which then weakens TCR signaling in T cells, reduces Th1/Th17 differentiation

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A phase II study used tamoxifen plus melatonin (20 mg/day) in the treatment of metastatic breast cancer which had progressed under treatment with tamoxifen alone

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Methods Animal studies Animals were used in strict accordance with ethical guidelines of the Scripps Research Institute (Scripps Research IACUC protocol no