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Mdm2 and Mdmx Promote Ferroptosis by Pparalpha-Mediated Lipid Remodeling

This can lead to a loss of electrolytes, potentially stressing the kidneys and making underlying conditions worse

Although results of studies carried out to date do not confirm associations between GSTM1 , GSTT1 , and GSTP1 and epithelial ovarian cancer, the associations are biologically plausible because glutathione S -transferases metabolize exogenous and endogenous substances that may have a role in ovarian cancer carcinogenesis

As the disease progresses, damage to the antioxidant system, excessive OS, and altered Nrf2 expression levels, especially the inhibition of ferroptosis by lipid peroxidation inhibitors and adaptive enhancement of Nrf2 signaling, suggest that Nrf2 is essential for the detection and identification of ferroptosis and potential clinical implications of targeted therapy for neuronal loss and dysfunction

2013 Sep