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IGF-1 is a strong stimulator of sebaceous lipogenesis and acne pathogenesis has been linked to elevated IIS with consecutive nuclear FoxO deficiency [16, 17]

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doi:10.3390/ANTIOX12020393 Sun Y, Liu W, Zhang H, et al

At predetermined time points (2, 6, 12, and 24 h post-administration), the mice were euthanized, and the residual gel on the skin surface at the application site was removed by washing with PBS