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Dominance of the inactive asian variant over activity and protein contents of mitochondrial aldehyde dehydrogenase 2 in human liver

[25] Artesunate is also used to treat less-severe forms of malaria when it can be given orally

Collagen is a protein that gives the human body structure

importantly, cumulative exposure (measured in pack-years) was strongly associated with fibrosis severity, with each additional pack-year tripling the likelihood of advanced fibrosis (adjusted OR per pack-year: 3.2

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Mechanistically, multi-omics analysis revealed that FSP1 interacts with pyruvate kinase M2 (PKM2), a key rate-limiting enzyme in the glycolytic pathway [21], to enhance glycolytic flux, resulting in lactate accumulation within macrophages