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46 Chris Masterjohn, Ph.D.: Navigating the many pathways to health and disease NAD and sirtuins, methylation, MTHFR and COMT, choline deficiency and NAFLD, TMAO, creatine and more Peter Attia MD The Dangers of Proton Pump Inhibitors Chris Kresser SNR #129: Chris Masterjohn, PhD Glycation, Oxidative Stress & The Protective Effects of Glucose and Insulin Sigma Nutrition Food First, Pharma Last Part Two of our Interview with Chris Masterjohn Regulatory Effects and Molecular Mechanisms of Tea and Its Active Compounds on Nonalcoholic Fatty Liver Disease Journal of Agricultural and Food Chemistry Proton pump inhibitors have a half life of 0.5 2 hours but they irreversibly inhibit the proton pumps; hence, their action persists for 24 48 hours. They are therefore known as 'hit and run drugs'. The hit and run

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