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The resultant increase in lactate levels can induce lactylation of the mitochondrial fission 1 protein, exacerbating sepsis-induced acute kidney injury

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7 , R100 (2006)

Removal of opioid/acetaminophen combination prescription pain medications: assessing the evidence for hepatotoxicity and consequences of removal of these medications

However, oxidative stress can also increase in response to stress and other health conditions, including migraines and both acute and chronic fatigue 50,51