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In particular, there have been many breakthroughs in the design of DON prodrugs, by modifying the carboxyl and amino groups of DON to obtain prodrugs that are not metabolized in plasma but decomposed in target cells, including acetyllysine substituted DON and JHU-083

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M., VCAM1 Signals During Lymphocyte Migration: Role of Reactive Oxygen Species, Molecular Immunology 39 (2002): 499508, 10.1016/s0161-5890(02)00206-7

There is a general expectation that by careful selection of dsRNA length and sequence (Chen et al.), RNAi can be limited to target insect pests without any direct harmful effects on non-target species, including beneficial insects such as pollinators and biological control agents (Zotti et al., 2018)