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However, keeping an elevated intracellular ROS level within AML cells without altering their viability and proliferation potential requires the establishment of a set of detoxification mechanisms to support their continued growth [33]

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Refractory Severe Aplastic Anemia Eltrombopag was studied in a single-arm, single-center, open-label trial (Study ETB115AUS28T, referred to as Study US28T [NCT00922883]) in 43 patients with severe aplastic anemia who had an insufficient response to at least one prior immunosuppressive therapy and who had a platelet count less than or equal to 30 x 109/L

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362 Napabucasin disrupts STAT3 and NF-B signaling, inhibiting GBM cell proliferation, colony formation, and invasion, while in vivo studies have confirmed its efficacy in impairing GBM growth in xenograft models