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doi:10.1002/hep.20800

Similar effects are observed in CVD, where preclinical murine models reveal Nrf2-HO-1 signaling to also exhibit a dual anti-inflammatory and cytoprotective function

Nrf2 mRNA expression was reduced by 50% at 48 h and by 70% at 72 h after transfection (Supplementary Fig

S.HuW.JiangD

Furthermore, ROS can enhance the expression of pro-inflammatory chemokines and cytokines, leading to the recruitment and activation of immune and inflammatory cells