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Nrf2 generally binds to Keap1 in the cytoplasm of normal cells (Itoh et al., 1999), and Keap1 degrades Nrf2 to balance Nrf2 protein expression

10.1111/j.1753-4887.2007.tb00311.x 55 KoC

Discussion: To counteract the condition of oxidative stress, synthetic antioxidants must be provided from external sources to supplement the antioxidant defense mechanism internally