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Preclinical toxicology studies in rodents showed no significant hepatotoxicity, nephrotoxicity, or hematologic abnormalities at doses equivalent to 100200mg daily in humans

For three or more groups, when the main issue was whether a significant difference between groups and whether there are interactions between factors, one-way ANOVA or Kruskal Wallis ANOVA was performed depending on normality

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This article does not assert that combining them produces additive or synergistic effects in any model system

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