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Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines

Importantly, c-MET has also been associated with chemoresistance by bypassing traditionally clinically inhibited signals such as EGF

a given molecule can be written in many ways, and even RDKit standardization and canonicalization workflow is not always able to detect such cases

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Synthesizing this data into actionable dosing protocols requires understanding the context behind each number