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Global Investigative Journalism Network

In fact, a deficiency of vitamin B12, folate, or vitamin B6 may increase blood levels of homocysteine

Ann Emerg Med 77:654656 Liebman HA, Weitz IC (2017) Autoimmune hemolytic anemia

Other forms, including methylcobalamin and adenosylcobalamin, are available as well (130)

Because SAM is required for hundreds of methylation reactions, including those that build creatine and glutathione, low levels of SAM can ripple across nearly every body system