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This lack of efficacy may be attributed to the low plasma and sputum concentrations of NTZ and the high plasma protein binding of tizoxanide, the active metabolite of NTZ [80], highlighting the need for further pharmacokinetic optimization and clinical research to better understand its potential role in TB treatment

Zhu H, Xiao X, Zheng J, Zheng S, Dong K and Yu Y 2009 Growth-promoting effect of bisphenol A on neuroblastoma in vitro and in vivo

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10.1016/j.neuron.2023.08.012 92 KimH.DuF.FangM.WangX

Once TMAO formation/concentration is elevated, it may increase the risks of atherosclerosis for healthy individuals ( TMAO and HF HF is defined as a group of syndromes caused by structural or functional damage that results in impaired ventricular filling or cardiac output, and which involves multi-organ and systemic neurohumoral dysfunction (89)