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Mol Cancer (2019) 18:103

Rossler OG, Bauer I, Chung HY, Thiel G

If prescribed, Placebo patients received 32 mg methylprednisolone, while larsucosterol-treated patients received matching placebo capsules

GPX4 uses glutathione as a cofactor to reduce peroxides to their corresponding alcohols, which is important in blocking the formation of reactive oxygen species and subsequently preventing oxidative damage

Cell Death Differ 25:4655 Redza-Dutordoir M, Averill-Bates DA (2016) Activation of apoptosis signalling pathways by reactive oxygen species

Peak concentrations occur within minutes of infusion initiation and decline rapidly through distribution and renal filtration, with a plasma half-life of roughly two hours in adults with normal kidney function