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The transition from notochordal cells to chondrocyte-like cells is currently debated, with some evidence that notochordal cells are completely replaced with chondrocyte-like cells in certain model systems while other studies show retention of a population of notochordal cells past early developmental stages (Minogue et al., 2010

These findings are supported by in vivo research, such as the study by Muizzuddin et al

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