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After the MPTP protocol, two monkeys exhibited evident parkinsonian signs, two animals only displayed mild signs, and the last two showed no apparent parkinsonism

Biochemical Journal, 258 (1), 267-272

The studies confirmed the GHRH receptor pharmacological profile of the tetrasubstituted scaffold that underpins both variants, with the no-DAC form studied as the pulsatile delivery model and the DAC form providing the prolonged pharmacokinetic extension of that same receptor biology