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These findings suggest a potential link between ammonia accumulation and immune checkpoint expression, implying that ammonia accumulation can promote immune checkpoint expression in immune cells, leading to tumor drug resistance and immune evasion

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In biological systems, T?4 plays a central role in processes including wound repair, angiogenesis, and inflammation control[1]

YY1 complex in M2 macrophage promotes prostate cancer progression by upregulating IL-6