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however as the disease progresses, pathogens in the microbiome disable the immune response and immune exhaustion occurs (233, 234)

Microbial ecology: human gut microbes associated with obesity (in Eng)

Since the hallmark of SCD is chronic hemolysis with excess hemin producing significant levels of oxidative stress, we speculate that hemin may modulate TSS pathway function

Advanced strategies using nanoplatforms and combinatorial therapies have shown promise

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Therefore, it is recommended to use a combination of methods, such as flow cytometry with confocal laser scanning (CLS) microscopy [86] or stereological sampling techniques with transmission electron microscopy [87]