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Third, a C20 fatty acid chain attached to the N-terminus promotes albumin binding in the bloodstream, which is the modification responsible for the dramatically extended half-life

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Its pharmacologic activity is destroyed by heavy metals (iron) and strong oxidizing or reducing agents (vitamin C), but not by autoclaving for short periods of time (15-20 minutes) at 121C

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Similarly, NRK2 protein and mRNA levels largely increased in the failing heart, in both mice and humans [90]