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121 In general, most nutrients that stimulate insulin secretion also increase proinsulin biosynthesis, with glucose the most physiologically relevant one

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Annual Review of Neuroscience, 21 , 127148

Different tumor subsets, individual tumors, and even subpopulations within single tumors exhibit distinct metabolic preferences influenced by genetic drivers, microenvironmental factors, and therapeutic pressures

Measurements of suitably selected serum markers could potentially provide a non-invasive and easily applicable solution to this challenge