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This could potentially initiate a cycle of amplified oxidative damage and depletion of antioxidants such as glutathione (GSH) ( 3.2 4-Hydroxynonenal as a cytotoxic effector Hz-triggered peroxidation of polyunsaturated fatty acids (PUFAs) non-enzymatically generates 4-hydroxynonenal (4-HNE), a highly reactive lipid peroxidation end-product (Skorokhod et al., 2005)

doi: 10.1186/s12882-022-02794-8 7

Vitamin B12 plays an important role in the production of myelin, a fatty substance that surrounds your nerves, insulating and protecting them