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Curr Drug Metab 12, 818822 (2011)

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PloS Biol (2015) 13:e1002202

displayed the significant role of Hedgehog downstream effector polycomb complex protein BMI-1 (BMI-1) in mediating lysophosphatidic acid pro-tumorigenic activities through inhibition of autophagy, and the capability of resveratrol to prevent Hedgehog pathway and BMI-1 activation to rescue autophagy and dampen the malignant features of ovarian cancer cells

EPA category II (i.e., oral LD 50 500 mg/kg), LD 50 following intraperitoneal dosing to rats and monkeys is 60-85 mg/kg and 32 mg/kg, respectively [415]

In light of the proposed changes to the wage index and other proposed wage index policies for FY 2024 discussed previously, which directly affect the GAF, we are proposing to continue to compute a budget neutrality adjustment for changes in the GAFs in two steps