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Their simultaneous activation does not produce simple pathway redundancy but rather engages complementary aspects of the tissue repair response, providing the biological rationale for studying whether combination produces additive or synergistic repair outcomes exceeding either peptide alone

Abbreviations LiP: lignin peroxidase VP: versatile peroxidase VE dimer: veratrylglycerol-beta-guaiacyl ether VA: veratryl alcohol LRET: long-range electron transfer ABTS: 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonate LC-MS/MS: liquid chromatography-tandem mass spectrometry CBB: Coomassie brilliant blue G-250 VAD: veratraldehyde IEF_PCM: integral equation formalism polarizable continuum model DFT: density functional theory References Tien M, Kirk TK