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Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation

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After analyzing blood and tumor samples that had been collected over time from some participants, one finding of particular interest was that treatment with atezolizumab could "convert" tumors from those that initially lacked one of two proteins, PD-1 or PD-L1, needed for atezolizumab to work, to those that eventually produced high levels of either protein

Brain 132:32853297

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Wu et al., 2017), the detailed mechanisms of which have been discussed in a previous review (Koppula et al., 2018)