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Exenatide-Modified deferoxamine-based nanoparticles ameliorates neurological deficits in Parkinsons disease mice

Cremophor EL acts as an absorption enhancer (Li et al., 2016b), improving drug bioavailability, brain targeting, and facilitating BBB penetration (Kotta et al., 2021)

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Furthermore, secreted TFF2 accelerated hepatic CD4 T cell proliferation and differentiation into Th1 and Th17 cell through CXCR4-STAT1/3 signaling pathway

Consistent with this structural analysis, alanine mutations of the GSH-interacting residues (R435A, R439A, N498A, Q501A, N545A, T549A, and R552A) led to a partial or complete loss of stimulated ATPase activity (Fig