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10.3390/CANCERS13174404 28 JungY

Int J Cardiol 2010

But because psoriasis is a systemic immune condition, systemic delivery may be necessary to address the underlying immune dysregulation

Preprint at bioRxiv , (2021)

Melov S, Adlard PA, Morten K et al (2007) Mitochondrial oxidative stress causes hyperphosphorylation of tau

For context, human safety testing found no meaningful irritation from creams containing centella extract at everyday use levels (the tested amounts were well under 1%)