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ROS are necessary for appropriate cellular signaling and homeostasis within a certain range, but their excessive generation, combined with reactive nitrogen species (RNS), causes oxidative stress, which is a major contributing component to the pathophysiology of neuropathic pain [16, 17]

doi: 10.1128/mSystems.00130-17 74 SunMWuWLiuZCongY

No significant inter-group difference was observed with regard to the primary outcome (physical function on the Short-Form 36 subscale at 6 months) [168]