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The level of dihydroorotate dehydrogenase (DHODH) was significantly reduced in neurons treated with oxyhemoglobin, a reduction mediated by the CGAS/STING pathway (You et al., 2025)

The Arthritis Foundation estimates about 6 million American men and 2 million American women have gout

Caloric restriction impairs regulatory T cells within the tumor microenvironment after radiation and primes effector T cells

Furthermore, the expression of antibiotic class-specific influx channels and their functional overlap, and the fact that many metabolites impact several metabolic pathways, complicate the design of effective interventions targeting membrane permeability