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The Keap 1-Nrf 2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis

Since the gut is a gateway for environmental pathogens to enter, and the CNS and ENS participate in pathogen resistance mechanisms, the microbial flora and their metabolites are essential for promoting tight-junction expression and maintaining bloodbrain barrier (BBB) function ( Drosophila model of AD (Wu et al., 2017)

Mengyue W., Weiwei L., Miaomiao W., S.Z., M.Z., Y.X., X.S., Z.L., X.L., and Q.T., performed the experiments

Approximately 15% of the nanoprobe crossed BBB and entered the brain parenchyma, which was much higher than the levels reachable by the traditional pathways 12,13

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ERAP1 controls the autoimmune response against melanocytes in psoriasis by generating the melanocyte autoantigen and regulating its amount for HLA-C*06:02 presentation