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Results HIV-1 JR-CSF infected microglia integrate into neural organoids and transfer viral particles to astrocytes, not neurons As a model to study the impact of HIV on the CNS and the role of metabolic reprogramming due to infection, we generated regionalized neural organoids with a forebrain identity, hereafter called neural organoids (NO) and co-cultured with HIV-1 JR-CSF infected microglia (HIV-MNO) or mock infected microglia (mock-MNO) (Fig

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Obomeghei et al., 2022

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