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Results IGF-enriched pathways include activated cell cycle, DNA replication and repair and suppressed immune pathways As a first step to investigate associations of IGF axis components with immune factors, we analyzed effects of IGF-1 on gene expression in three PCa cell lines: two human, androgen receptor (AR)-positive 22Rv1 cultured from a xenograft established from primary PCa, and AR-negative DU145 derived from metastatic cancer