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FIGURE 1 We review below general PKC function in relation to psychiatric illness with a focus on drugs affecting PKC pathways, with emphasis on the function of PRKCG, given its almost exclusive presence in neural tissue

A comprehensive review was conducted of PubMed citations containing the key word marker OR biomarker combined with migraine OR headache. Other key words included serum, saliva, cerebrospinal fluid, genes, blood, and inflammation. The only restriction was English-language publication

3 In the United States (US), kratom use has proliferated in the past decade and is used typically in the form of capsules, powdered leaves consumed either dry or as a tea, in energy drinks, and in elixirs

Supplementary material The Supplementary Material for this article can be found online at: References 1 GuoWWangXLuBYuJXuMHuangRet al

Stoyanovsky DA, Tyurina YY, Shrivastava I, Bahar I, Tyurin VA, Protchenko O et al (2019) Iron catalysis of lipid peroxidation in ferroptosis: regulated enzymatic or random free radical reaction