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MFPDS: 31.2 1.9 versus 37.7 2.4, p = 0.047)

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Adipex and Suprenza (phentermine) Qsymia (phentermine-topiramate) Contrave (naltrexone-bupropion) Xenical and Alli (orlistat) Imcivree (setmalanotide) Plenity (carboxymethylcellulose hydrogel) Several additional agents are used off-label for weight loss at acceptable risk when prescribed thoughtfully and documented as off-label

This is why injections are often discussed when the target is not mainly the gut