glutathione ros nac N-acetylcysteine (NAC) attenuates the increase in levels and the International Journal of Molecular Medicine

10.1007/978-1-0716-4298-6_19 258 TempletonA

and caveolin-1 (CAV1), a scaffold protein of caveolar membranes involved in signal transduction and in the uptake of lipophilic compounds, which directly interacts with NRF2, probably competing with KEAP1 for binding to NRF2, and subsequently suppresses its transcriptional activity [231]

Curcumin has significant anti-inflammatory effects, mainly by downregulating the NLRP3 inflammasome, and regulating NF-B signaling and interleukin secretion are the most prominent functional mechanisms of curcumin in modulating the inflammasome (76), thus potentially focusing more on improving the inflammatory levels in PCOS patients

Possible significance and implications for novel mediator

Skin brightening and lightening: Helps improve uneven tone and reduce the appearance of hyperpigmentation 2

Metabolic syndrome in hypopituitarism