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Biological characteristics of age-related changes in C57BL/6 mice sub-strains in the national center for geriatrics and gerontology aging farm

Disclosure of interest: Sheng Yang and Alastair Webb: nothing to disclose Poster Session II - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.02 - GENETICS, OMICS AND BIOMARKERS P1086 - ESOC25-803 ASSOCIATIONS OF MRI INDICES OF GLYMPHATIC FUNCTION AND DISEASE SEVERITY IN CADASIL Yunqing Ying 1 , Rong Zhou 1 , Xin Cheng 1 1 Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China Background and Aims: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary cerebral small vessel disease (CSVD)

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These well-characterized findings show that immature red blood cells suffer ferroptosis stress from iron accumulation and oxygen during stress erythropoiesis, while ferroptosis is rarely detectable in normal red blood cells

The recombinant At-NEET homodimer coordinates two labile 2Fe-2S clusters, which are readily transferred to apo Fd in in vivo assays (Nechushtai et al., 2012)

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